Importantly, in pathological conditions such as pulmonary arterial hypertension or cardiac fibrosis, more than one member of the LOX family may be upregulated
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In another case, detailed in the American Journal of Gastroenterology, a 60-year-old woman underwent a coffee enema and later suffered severe inflammation of the colon
We demonstrated that, at low doses (ng), local (intraplantar) or systemic (intraperitoneal) injections of thymulin resulted in hyperalgesia with an increase in proinflammatory mediators, and that this peptide could act directly on the afferent nerve terminals through prostaglandinE2 (PGE2)dependent mechanisms, thus forming a neuroimmune loop involving capsaicinsensitive primary afferent fibers