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Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11

These compounds demonstrate antagonistic activity to the heat-sensitive transient receptor vanilloid 1 (TRPV1) in vitro and in vivo [27]

Figliuolo, V

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However, these findings were not validated in animal models, and key pharmacological parametersincluding fertility outcomes, long-term toxicity, and pharmacokineticsremain uncharacterized

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