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The proposed mechanism involves upregulation of vascular endothelial growth factor (VEGF) and modulation of the nitric oxide (NO) pathway

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Researchers have noted an overlap that often occurs between people with Ehlers-Danlos and mast cell activation syndrome.[ref] Related article : Check your 23andMe data for Ehlers-Danlos Syndrome genes POTS Postural orthostatic tachycardia syndrome: There is an overlap in some patients between MCAS and postural orthostatic tachycardia syndrome (POTS), a common type of dysautonomia

MOTS-c : the 2015 and 2018 Cell Metabolism papers cover the therapeutic animal story here

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A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction