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Consequently, long-term maintenance therapy is needed for most patients since symptoms often recur when PPI therapy is discontinued

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The dose in weekly tirzepatide injections is far below the amounts used in sleep studies, however

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B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers