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This kind of conformational change is made possible due to the weak association between K3 and NK2 domains in HGF

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In some embodiments, the tympanic membrane is anesthetized by any suitable method (e.g., use of phenol, lidocaine, and xylocaine)

It is worth noting that cellular senescence also plays important beneficial roles in physiological processes such as tissue development, wound healing, and tumor suppression (Suter et al., 2025)