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Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity

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In contrast, ligand binding to TLR3 and TLR4 receptors leads to the activation of interferon-regulatory factors (IRFs), particularly IRF3, resulting in the production of Type I interferons (IFN- and IFN-) necessary for antiviral defense [232]