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Robust co-precipitation of TBC1D9B-domains with TMEM55B-eGFP was observed for the C-terminus, the N-terminus, and the TBC + EF-hand domains, but not for the TBC-domain alone

This starves the mitochondria of necessary fuel, further exacerbating the cellular energy crisis and deepening the fatigue

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

The position of these Na + -independent transporters ensures AA availability in the brain and also its bidirectional transport across the endothelial cells

Targeting the Microenvironment of Melanocytes Besides melanocytes and keratinocytes, other players, such as dermal fibroblasts, immune, and endothelial cells, are involved in the development and relapse of hyperpigmentation [24, 152,153,154]

This explains why intracellular oxidation kinetics for roGFP2 fusion constructs with glutaredoxin mutants showed excellent correlation with the second order rate constants of the oxidative half-reaction from in vitro experiments 15,26,34,35