glutathione ncbi Multiomics reveals metabolism as a driver of bimodality during stem cell aging: Cell Metabolism glutathione reduced peroxinitrite reduced chemotaxis

This cascade response is triggered by an extracellular signaling molecule, AI-2, at a certain threshold concentration (Moreno-Gmez et al., 2017)

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Oncotarget (2018) 9(38):2498091

Liver repair and regeneration exhibit several commonalities across different conditions, such as the activation of inflammatory and growth factor signaling pathways, including TNF-, IL-6, HGF, and EGF, which play crucial roles in hepatocyte proliferation and tissue repair

Grx activity depends on both GSH and GR for regeneration of GSH from GSSG, meaning this system is functionally dependent on the GSH system

GSH effectively scavenges free radicals and other ROS and RNS (e.g., hydroxyl radical, lipid peroxyl radical, superoxide anion, and hydrogen peroxide) directly and indirectly through enzymatic reactions