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Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

methylmalonyl CoA mutase converts methylmalonyl CoA to succinyl CoA, with 5-deoxy adenosyl cobalamin required as a cofactor

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A safety-first approach matters because: Supplements arent regulated the same way as prescription medications, and dosages/quality can vary

B12 also helps the body convert food into energy

Stimulants cause tolerance development, meaning increasing doses are needed for the same effect