Stimulation of matrix synthesis In fibroblast cultures, GHK-Cu increases the synthesis of the major structural molecules of the extracellular matrix: collagen, elastin, and the glycosaminoglycan/proteoglycan ground substance (including dermatan sulfate and other glycosaminoglycans)
For hair growth specifically, combining topical GHK-Cu with microneedling is supported by the strongest evidence as shown in the 2025 Kuceki study which achieved 26.5% regrowth with this combination approach
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10.1016/j.foodchem.2009.11.052 30 LeeH.-J.LeeS.-A.ChoiH