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TUNEL method revealed a marked accumulation of DNA fragments in both the cytoplasm and nucleus of necrotic hepatocytes in the Aldh2*2 KI homozygous mice after AA exposure (Fig

doi: 10.1073/pnas.2000640117 56 GiovannoniF.QuintanaF

Our finding implies that ALDH2*2 carriers may have a risk of systemic damage upon exposure to high levels of aldehydes exogenously and/or endogenously

Yes, research suggests that NAD and Glutathione may support brain health and potentially slow the progression of neurodegenerative diseases like Alzheimer's and Parkinson's by enhancing DNA repair and reducing oxidative damage