Strategies aimed at reducing high glucose levels by employing sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to significantly lessen the onset of cellular senescence, potentially attributed to the synthesis of -hydroxybutyrate ( Telomere shortening is a widely recognized occurrence in both type 1 and type 2 diabetes, and this process may be hastened by factors such as inflammation, hyperglycemia, glycation end products, and persistent oxidative stress (Sutanto et al., 2019
In certain areas of the world where G6PD deficiency reaches epidemic proportions and ingestion of fava beans is staple, screening for endemic G6PD-deficient variants and avoiding fava beans in those that are G6PD deficient reduces hospitalizations and RBC transfusions
Transportation of nutrients thoughout the body
do not assume a standard concentration
Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U et al (2002) Regulation of intracellular pH in human melanoma: potential therapeutic implications
Cost is higher