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A mouse model of vitiligo with focused epidermal depigmentation requires IFN-gamma for autoreactive CD8(+) T-cell accumulation in the skin

Physiol Rev 94(2):32954

The resistance to endocrine treatments including tamoxifen, aromatase inhibitors, and selective ER degraders is protected by dysregulation of these pathways, which in turn fuel hormone-dependent tumour growth (187, 188)

The ARTG is a publicly accessible database of products which can be lawfully marketed in Australia

If you understood the mechanisms that lead to failure over time, you might intervene with another drug that targets that specific immunological mechanism thats gone awry, Herold says

It is typically employed in acetaminophen toxicity, respiratory mucus disorders as well as supportive care