Increased HIF-1 activity is also observed for other iron chelators, such as salicylaldehyde isonicotinoyl hydrazone (SIH) and deferiprone ( FIGURE 11 Among the DFO analogs are those where the DFO molecule has been attached to various high-molecular weight polymers, including cellulose, dextran, or hydroxyethyl starch
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GSH levels in macrophages, directly affect the Th1/Th2 cytokine response, and more specifically, GSH depletion inhibits Th1-associated cytokine production and/or promotes Th2 associated responses (Fraternale et al., 2006)
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