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So, if you're feeling unwell due to a deficiency, restoring B12 levels might help you feel well enough to eat normally, but it's not "making" you gain weight in an unhealthy way

However, some conditions and medications may cause some people to become deficient

Mechanistically, it upregulates VEGFR2 signalling, stimulates angiogenesis and fibroblast proliferation, and modulates the inflammatory cytokine response [3]

In fact, some observational studies suggest slightly lower fracture risk at high B12 blood levels

But tirzepatide doses tend to be higher (up to 15mg weekly), requiring different water volumes to keep injection volumes manageable

The compounds effects on fat metabolism are particularly noteworthy