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Acute hepatitis was reported following intake of greater celandine [ Chelidonium majus ], widely used to treat gallstone disease and dyspepsia [44,218]

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A broader review found it might brighten skin in sun-exposed areas but labeled the overall evidence as "inconclusive" due to mixed study quality (PubMed Systematic Review)

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The detailed elucidation of these multiple ROS sourcesmitochondria, NADPH oxidase, xanthine oxidase, and CYP450 enzymesreveals that oxidative stress in PCOS is a complex, multi-factorial burden, not attributable to a single pathway