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PMID: 20346541 Velissariou I et al

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When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]

These include the following: therapeutic benefits resulting from non-antioxidant mechanisms, insufficient dosage to elicit an antioxidant effect, poor oral bioavailability, a narrow therapeutic index, or toxicity that precludes clinical use

Delayed neurocognitive recovery Delayed neurocognitive recovery (NCR), a common postoperative neurological complication in the aged, is characterized by acute cognitive dysfunction and memory deficits

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