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Consequently, modulation of these shared nodes (whether through iron chelation, GSH restoration, GPX4 stabilization, or lipid peroxidation inhibition) may offer broad-spectrum therapeutic strategies, providing a theoretical foundation for developing pan-pathogenic antimicrobial agents

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They have been extensively studied in large randomised controlled trials, with success rates of 60-70% across various causes of ED

An important aspect that have emerged is the broad spectrum of effects covered by the angiogenic inhibitors and the diversity in terms of therapeutic response [305]