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Melasma Oxidative stress that occurs in melanocytes also significantly contributes to the development of melasma, a skin disorder characterized by hyperpigmentation on sun-exposed areas of the skin 123

Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-B-mediated matrix metalloproteinase-9 expression

However, the daily insulin requirement between the two groups did not show a significant difference [63]

This may contribute to its observed effect durability

Yang, X.-F