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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

Thus, there is a need for larger studies to fully address this issue

Although residues C32 and C88 of PfGrx are redox-inactive during the monothiol mechanism, they both facilitate the deglutathionylation of GSSR substrates

[DOI] [PubMed] [Google Scholar] Nslund J., Haroutunian V., Mohs R., Davis K.L., Davies P., Greengard P., Buxbaum J.D

3 BanningA.FlorianS.DeubelS.ThalmannS.Mller-SchmehlK.JacobaschG.et al (2008)

The drink may taste fine during the initial phase, but could develop aftertaste within 3060 days