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The misalignment of the circadian clocks, the internal timekeeper mechanism that links metabolism with the exogenous and endogenous factors, has been associated with the acceleration of aging

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Interestingly, a typical 400mg dose of amiodarone in adults leads to a peak plasma concentration in the same order of magnitude as the IC 50 value we measured here (Goldschlager et al., 2000)

This provides a massive influx of nutrients and repair signals directly to poorly vascularized tissues, such as tendons and ligaments, which normally heal very slowly

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