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Cell 2018, 173 (7), 15811592
Frequency of esophagogastric junction involvement among upper gastrointestinal cancers
Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels
Rao M, Gao C, Hou J, Gu J, Law BYK, Xu Y
This and other recent findings have led some to suggest that 11KT may in fact be the most physiologically relevant androgen in women, though more work is needed to investigate this [288]