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Manipulation of genes encoding enzymes for, e.g., folate biosynthetic and salvage pathway, polyglutamylation, and folate binding proteins, has been carried out with some achievements 2,10,25,34,303,310,560,752,754,776,791,792,793,794,795,796,797,798,799,800,801,802

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5-Oxoprolinuria in hyperammonemic encephalopathy: coincidence or worsening factor

Cytokine release syndrome in severe COVID-19

In addition, we implemented a Random Forest (RF) classifier on the dataset, allowing the model to inherently perform feature selection through its importance ranking, and assessed performance using AUC and precision-recall AUC (PR-AUC)

This is because B12 is only found naturally in animal foods