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This includes patients receiving intramuscular injections (typically 1,000 micrograms) for pernicious anaemia or documented B12 deficiency, as well as individuals taking high-dose oral supplements exceeding the Reference Nutrient Intake (1

(4) Research has demonstrated that NNMT inhibition results in increased intracellular nicotinamide and SAM levels

This connection between vitamin B12 and mental well-being is particularly significant, as studies have shown that low levels of this vitamin can contribute to mood disorders, including depression and anxiety, highlighting the need for adequate intake throughout life

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