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In the presence of methylene blue there is a very considerable increase in the production of [14C]carbon dioxide from [14C-1]glucose, and a corresponding decrease in the label in lactate and pyruvate, although the total radioactivity in (lactate + pyruvate + carbon dioxide) is the same as in the control incubation

The details are included in B12 Supplementation Trials, but the baseline parameters were such outliers, and the response to treatment was so drastic, that the lines didnt fit in the charts

They are particularly beneficial for older adults and those with conditions that impair B12 absorption

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10.1016/j.fertnstert.2007.11.021 118

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