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Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent

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Based on the available data we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome

Integrative Medicine: A Clinicians Journal

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In one study, people with obesity who received vitamin D supplements in addition to following a weight loss diet plan lost more weight and fat mass than the members of the placebo group, who only followed the diet plan