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The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior

In vitro experiments and neonatal animal models of HI suggested a very complex network of cell death cascades, highlighting a continuum from apoptosis to necrosis 33,34

The neurodevelopmental consequences of brain injury include death, cerebral palsy, severe intellectual disabilities, blindness, deafness, and a number of minor behavioral and cognitive deficits