Aberrations in temporal rhythms can both directly and indirectly enhance cardiovascular and cerebrovascular disease (Bggild and Knutsson, 1999), by enhancing sympathetic drive (Morris et al., 2012) increasing obesity (Shi et al., 2013), inducing insulin resistance and metabolic disorders (Marcheva et al., 2013), promoting premature aging (Brown et al., 2011), and inflammatory pathologies (Savvidis and Koutsilieris, 2012
It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage
M.et al (2012)
Mycotoxins may induce cellular senescence by activating reactive oxygen species (ROS)-induced oxidative stress
Severe deficiency of vitamin B 6 is uncommon, but alcoholics are thought to be most at risk due to low dietary intakes and impaired metabolism of the vitamin
2.Can you make designs for us