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While traditionally considered as cytosolic enzymes, work in Arabidopsis has revealed that several isoforms may localize at least partly to other compartments, including the chloroplast, peroxisome, and nucleus (Thatcher et al., 2007

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Together these molecules constitute the **reference pairing** in tendon, ligament, muscle and vascular repair research: two complementary mechanisms of action, one shared angiogenic vector, and dramatically expanded tissue coverage

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Address methylation bottlenecks Distinguish low SAM from high SAH Review homocysteine, adenosine-related metabolism and kidney function Support transsulfuration and glutathione when appropriate Avoid automatic folate or methyl-donor treatment 6