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Insufficient human clinical trials have led to a lack of data to determine a safe dose

In general, organ meats, like kidneys or livers from animals, are very high in B12

However, in unpredictable situations where requirements can shift rapidly and stakeholder needs evolve during the project's execution, providing value and ensuring satisfaction is more effectively achieved through an adaptive management approach

What they did: Isolated human chondrocytes (from osteoarthritis patients and healthy donors) were exposed to AOD-9604 at doses 1 to 1000 nM