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Telomeres are protective segments of DNA located at the ends of chromosomes

Nitrous oxide (used in anaesthesia or misused recreationally) inactivates vitamin B12 and can precipitate or worsen neurological injury in patients with B12 deficiency

These may include: Nausea and stomach upset Diarrhea Constipation Injection site redness or swelling Itching Headache Dizziness Blood clots Swelling In rare cases, some people may experience an allergic reaction to vitamin B12, which can cause symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat

The final concentration is 1 mg per ml

We identified key regions in the p53 transactivation domain (TAD) involved in FOXO4 binding and designed an optimized peptide inhibitor (CPP-CAND) with improved cell permeability

PMCID: PMC9785784