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Before withdrawing medication from a vial, make sure its the correct medication, at the correct dose, at the correct time, and in the right manner

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Evening administration is as pharmacologically neutral as morning dosing

If something reduces the function of any of the organs that break down the B12, then the amount utilised can be even less

Timing matters too

Yes, small pilot studies have investigated intra-articular injection for knee osteoarthritis, with subjective pain improvement reported but no controlled trials completed