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Glucose 6-phosphate dehydrogenase, NADPH, and cell survival

Ullas Kamath et al., 2019

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This bidirectional regulation establishes a self-perpetuating cycle where initial ferroptotic events trigger inflammatory responses, which in turn promote additional rounds of ferroptosis in surrounding tissue

doi: 10.3390/cancers14061457 63 ZhangRLiuLWangFZhaoWLiuKYuHet al

The study demonstrated significant improvements in "on time" without troublesome dyskinesia, with an increase of 2.72 hours compared to 0.97 hours with standard oral LD/CD (95% CI 0.46 to 3.05