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This study demonstrates that Se can epigenetically modulate DNA and histones to activate methylation-silenced genes

We treated HCT116 cells with either DMSO (control) or 50 nM OTS964, isolated chromatin fractions, and digested them with micrococcal nuclease (MNase) 8,59,60

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J Hypertens 24:16631670 Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2