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The computed energy barrier for Cu(II)-catalyzed methionine oxidation is 14.3 kcal/mol significantly lower than for Zn (19.6 kcal/mol) or Fe (16.9 kcal/mol), making copper the most efficient catalyst among common metal ions

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However, for detection of its abuse in athletes, a solid-phase extraction method was validated in urine with a limit of detection of 50 pg/mL [2]