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Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance

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All animal procedures were reviewed and approved by the IACUC of the Atlanta VA Health Care System (Decatur, Georgia, USA) and were conducted in accordance with Animal Research: Reporting of In Vivo Experiments (ARRIVE) and NIH guidelines

In addition, DHAR, CLIC1 and GSTOs commonly contain a highly conserved catalytic cysteine residue and GSH binding residues near the active site

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