Kovtun et al., 2000
Each subunit of the dimeric isozyme consists of two functional domains, the more conserved N-terminal domain containing catalytically active cysteine, serine, or tyrosine residues, and the C-terminal domain
Rational targeting of GPX1, GPX4 and TXNRD1 holds high therapeutic potential in different pathological settings, where lipid peroxidation is either harmful or can be triggered for therapeutic purpose, as it is the case in numerous cancers and more particularly AML
10.1038/s41598-020-77328-z 72 HosseiniS.GhadimiM.ReyhaniN.KhazaeiS.Rahmatkhah-YazdiM.Soleimani-FarsaniR.et al (2025)
B12 supports the production of enzymes necessary to synthesize the nucleotides that are the building blocks of DNA
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