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Homocysteine is formed when SAMe, an important methyl donor, gives its methyl group to one of the following enzymes: GAMT to make creatine PEMT to make phospholipids COMT to metabolize estrogen HNMT to eliminate histamine PNMT to make epinephrine/adrenalin ASMT to make melatonin Because of this methyl group donation, SAMe becomes SAH

This is usually mild and subsides within a few days

However, certain medications or high-dose nutrients may require careful consideration

Feng Z, et al

One study highlighted that the peptide has a long history of safe use in wound healing and skin care