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Interestingly, the deletion of the ILK gene in MEFs also results in defects in the formation of acini in 3D culture similar to that which occurs when 1 integrins are deleted, suggesting that integrinILK linkages contribute to microtubule stabilization (Fig

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This condition results from disruption in glucose metabolism, often stemming from insufficient insulin production by the pancreas, reduced in insulin effectiveness in body tissues (insulin resistance), or a combination of these factors, which is particularly common among older adults [556]