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Yamane T, Murao S, Kozuka M, Shimizu M, Suzuki J, Kubo C, et al

Cardiopulmonary bypass (CPB) is related to multiple effects that may contribute to post-operative myocardial injury and cardiac dysfunction, including ischemiareperfusion injury after removal of the aortic clamp, the subsequent generation of reactive oxygen species, and increased production of inflammatory mediators [2, 3]

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An exciting group of RAAS modulators are biased AT 1 R ligands, such as -arrestins selectively binding on AT 1 R

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