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In animal models, tumor necrosis factor- perfusion of the CC showed weakened non-adrenergic non-cholinergic nerve-mediated relaxation, and the expression of endothelial NOS was inhibited [159]

10.18632/oncotarget.11687 29 DalenJ

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Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

Braun and Schweizer 2018

If you cannot obtain a new supply quickly, understand that stopping semaglutide suddenly may cause appetite rebound and other transitional effects