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Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives

Sterile handling supports accurate dosing and reduces contamination risks significantly

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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Senescent cells accumulate over time and are characterized by altered gene expression, resistance to apoptosis, and secretion of inflammatory mediators collectively referred to as the senescence-associated secretory phenotype (SASP)

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