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doi: 10.1038/sj.npp.1300752

Conventional in vitro systems, such as primary cardiomyocytes and H9c2 cell lines, have significant limitations in studying copper metabolism

Cross-referenced against the base protocols, the math gets striking fast

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Thus, in acromegaly, IGF-1 levels are elevated because of the somatotropinoma, but also because of the elevated insulin levels in the portal vein