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Hypertensive patients have been observed to produce high levels of hydrogen peroxide, superoxide anion, and NO in leukocytes [290,291,292], exhibit elevated lipid peroxidation in erythrocytes, and display elevated concentrations of 8-isoprostanes in plasma [293]

Mitochondrial dysfunction can also trigger inflammation through the activation of damage-associated molecular patterns (DAMPs), inflammasomes and inflammatory cells

In the last 25 years, several studies have tried to assess whether this could be replaced by oral supplementation