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A concentration of neurotransmitter serotonin, of which the disturbance in the early development plays a critical role in the establishment of innate anxiety, was increased in the prefrontal cortex of 3MST knockout mice 48

Our data showed that increased oxidative stress and mitochondrial dysfunction were involved in the pathogenesis of Fabry disease and were not fully eliminated even with ERT

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The TYR gene, involved in melanin biosynthesis in melanocytes, has been significantly associated with vitiligo in the European population.63 The roles of many susceptibility loci remain unknown, highlighting the lack of understanding in the etiopathogenesis of vitiligo, which continues to be a challenge today

Chemosphere 292, 133401

Tumor-induced immunosuppression, heterogeneous tumor microenvironments, and inefficient delivery of therapeutic agents often limit response rates and durability of treatment