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Kiprov DD, Herskowitz A, Kim D, et al

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The weight loss was consistent throughout the study period and showed a continued downward trend beyond week 36, suggesting a potential for sustained long-term activity

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This is likely due to the renal concentrating mechanism of filtered products from blood (80), which suggested that urinary metabolomic analysis might provide complementary information to plasma metabolomic analysis

In one aspect, PGC-1 upregulates the mRNA expressions of ERR in the heart, kidney, and muscle