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The known side-effect categories, with approximate frequencies drawn from pediatric and adult data, include the following: Injection-site reactions (common, ~17%): Erythema, pruritus, and transient induration

Stimulation of the Nrf2/ARE pathway is fundamental for the induction of antioxidant defense enzyme and the modulation of the intracellular GSH in response to stress (Liu et al., 2018a)

Crucially, besides inducing membrane depolarization through 7nAChR-gated Ca2+ conductance, there is growing evidence suggesting potential metabotropic activities of this ionotropic receptor [43]

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