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Routes of administration, elimination half-lives and tolerability vary among agents, although members of the same chemical class usually share similar pharmacokinetic characteristics

This accumulation causes significant inflammation and cell death in renal tubular epithelial cells (RTCs), ultimately resulting in renal calcification, hematuria, and, in severe cases, systemic oxalosis with progression to end-stage renal failure

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2013;40(4):3299314 A comprehensive review and meta-analysis reporting the estimated effects of GST genes on asthma, giving evidence for gene-environment interaction

class analogy applied