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In vitro experiments with SH-SY5Y neuronal cells demonstrated that palmitoyl-L-carnitine treatment enhanced tau phosphorylation, increased mitochondrial fission, and elevated intracellular calcium levels

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Correction for the spontaneous nonenzymatic reaction was obtained by subtracting the reaction rate of GSH with CDNB in the absence of the enzyme from the rate in the presence of the enzyme

Moreover, the choice of behavioral tests varies substantially across studies, which further complicates the interpretation of antioxidant effects

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