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The estrogen slows the production of FSH and LH and causes the uterus to grow an endometrial lining, where a potential embryo could implant if a pregnancy occurred during this cycle

It all comes down to absorption and timing

Br J Haematol 112(3):749-59, 2001

While individual responses can vary, restoring hormone balance often has a positive impact on daily motivation, cognitive sharpness and emotional well-being

And, I mean, I think we're going to see, I hope we're going to see, a lot more functional MRI type studies where people say, "Yeah, yeah, yeah

Long-term testosterone therapy can cause a decrease in sperm production